Uno is probably one of the first card games a lot of kids learn to play. I know that our kids were playing it from the moment they could recognize numbers. You've got to hand it to the Mattel folks -- they've managed to translate public-domain card games into merchandising empires. Uno, of course, is basically Crazy-Eights.
My mom and dad sent the kids Skip-Bo for their birthdays, and tonight after dinner they broke it out and played. I couldn't figure out what card game it was emulating until I looked it up on Wikipedia -- Spite and Malice! I had totally forgotten about that game. Our family went on a serious Spite and Malice kick sometime in the eighties, a few years after our King's Corner craze.
Now that the grandparents are here, I imagine we'll be playing games just about every night. They haven't stopped cycling through new games; a couple of years ago it was dominos, and now it's Rummikub. Maybe someday we'll make it all the way back around to the games we played growing up.